Owen Whitham

Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis

Mostafa Eltobgy, Ashley Zani, Adam D. Kenney et al. · Proceedings of the National Academy of Sciences · 2022 · 64 citations · Full text

Life Sciences, Immunology, Infectious Diseases +17

Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer’s disease

Asmaa Badr, Kylene P. Daily, Mostafa Eltobgy et al. · Brain Behavior and Immunity · 2024 · 29 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease

Kylene P. Daily, Asmaa Badr, Mostafa Eltobgy et al. · Alzheimer s Research & Therapy · 2024 · 15 citations · Full text

Life Sciences, Neurology, Neuroscience +17