Jan Eckmann

CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity

Isabelle Solomon, Maria Amann, Anne Goubier et al. · Nature Cancer · 2020 · 195 citations · Full text

Life Sciences, Immunology, Oncology +14

Protease-activation using anti-idiotypic masks enables tumor specificity of a folate receptor 1-T cell bispecific antibody

Martina Geiger, Kay‐Gunnar Stubenrauch, Johannes Sam et al. · Nature Communications · 2020 · 91 citations · Full text

Medicine, Cancer Biology, Oncology +17

RG6234, a GPRC5DxCD3 T-Cell Engaging Bispecific Antibody, Is Highly Active in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Intravenous (IV) and First Subcutaneous (SC) Results from a Phase I Dose-Escalation Study

Carmelo Carlo‐Stella, Rita Mazza, Salomon Manier et al. · Blood · 2022 · 90 citations

Medicine, Oncology, Pharmacotherapy +17

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

S. Jordan Kerns, Chaitra Belgur, Debora B. Petropolis et al. · eLife · 2021 · 75 citations · Full text

Life Sciences, Immunology, Oncology +15

The Tumor Milieu Promotes Functional Human Tumor-Resident Plasmacytoid Dendritic Cells in Humanized Mouse Models

Ilona-Petra Maser, Sabine Hoves, Christa Bayer et al. · Frontiers in Immunology · 2020 · 49 citations · Full text

Life Sciences, Immunology, Oncology +17