Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

Kazuya Shinozaki, Atsunori Kashiwagi, Yoshihiko Nishio, +5

Diabetes

Insulin SignalingOxidative StressMetabolic SyndromeVascular RelaxationNitric Oxide/o2- Imbalance +17

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

Masanori Ozaki, Seinosuke Kawashima, Tomoya Yamashita, +9

Journal of Clinical Investigation

Vascular DiseaseApoe-deficient MiceNitric OxideImmunologyAtherosclerotic Lesion Formation +14

Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice

Masanori Ozaki, Seinosuke Kawashima, Tomoya Yamashita, +9

Journal of Clinical Investigation

Vascular DiseaseApoe-deficient MiceNitric OxideImmunologyAtherosclerotic Lesion Formation +14

Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats

Kazuya Shinozaki, Yoshihiko Nishio, Tomio Okamura, +7

Circulation Research

Fulminant type 1 diabetes mellitus with anti‐programmed cell death‐1 therapy

Masahide Okamoto, Mitsuhiro Okamoto, Koro Gotoh, +9

Journal of Diabetes Investigation

ImmunohematologyImmunodeficienciesApoptosisImmunologyPathology +17

Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress

Kazuya Shinozaki, Atsushi Hirayama, Yoshihiko Nishio, +7

Journal of the American College of Cardiology

Metabolic SyndromeInsulin SignalingCoronary Endothelial DysfunctionVascular Oxidative StressCardiovascular Disease +11

The Effectiveness of GLP-1 Receptor Agonist Semaglutide on Body Composition in Elderly Obese Diabetic Patients: A Pilot Study

Yoshinori Ozeki, Takayuki Masaki, Akari Kamata, +5

Medicines

Decrease in tetrahydrobiopterin as a possible cause of nephropathy in type II diabetic rats

Michiaki Okumura, Masahiro Masada, Yuichi Yoshida, +7

Kidney International

Metabolic SyndromeGlomerulonephritisPossible CauseRenal FunctionBiochemistry +10

Pitavastatin Restores Vascular Dysfunction in Insulin-Resistant State by Inhibiting NAD(P)H Oxidase Activity and Uncoupled Endothelial Nitric Oxide Synthase-Dependent Superoxide Production

Kazuya Shinozaki, Yoshihiko Nishio, Kazuhide Ayajiki, +4

Journal of Cardiovascular Pharmacology

Development of a New Chemiluminescent Enzyme Immunoassay Using a Two-Step Sandwich Method for Measuring Aldosterone Concentrations

Yoshinori Ozeki, Yukie Tanimura, Satoshi Nagai, +11

Diagnostics