James Messing

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

Peiguo Yang, Cécile Mathieu, Regina‐Maria Kolaitis et al. · Cell · 2020 · 1.2K citations · Full text

Assemble Stress Granules, Triggers Phase Separation, Molecular Biology +5

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

Kyung‐Ha Lee, Peipei Zhang, Hong Joo Kim et al. · Cell · 2016 · 703 citations · Full text

Biochemistry, Cell Organelle, Membrane-less Organelles +11

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Ian R. Mackenzie, Alexandra M. Nicholson, Mohona Sarkar et al. · Neuron · 2017 · 635 citations · Full text

Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia +8

Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

Lindsay A. Becker, Brenda Huang, Gregor Bieri et al. · Nature · 2017 · 562 citations · Full text

Lifespan Extension, Knockout Mouse, Molecular Neuroscience +11

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

Peipei Zhang, Baochang Fan, Peiguo Yang et al. · eLife · 2019 · 263 citations · Full text