Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley, Daniel M. Kremer, H. Carlo Maurer, +27

Science

Cancer SLC43A2 alters T cell methionine metabolism and histone methylation

Yingjie Bian, Wei Li, Daniel M. Kremer, +26

Nature

ChromatinSystems BiologyChromatin RemodelingMedicineEpigenetic Change +9

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

Christopher J. Halbrook, Corbin Pontious, Ilya Kovalenko, +20

Cell Metabolism

OncologyPancreatic CancerMedicineAnti-cancer AgentPharmacology +2

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Weihua Zhou, Yangyang Yao, Andrew J. Scott, +25

Nature Communications

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

Daniel M. Kremer, Barbara Scott Nelson, Lin Lin, +31

Nature Communications

HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron

Rashi Singhal, Sreedhar R. Mitta, Nupur K. Das, +9

Journal of Clinical Investigation

Iron MetabolismPathologyCell DeathCrc CellsCancer Biology +16

GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

Dionysios C. Watson, Simon Storevik, Shannon Sherwin Moreino, +38

Nature Cancer

Intact MitochondriaNeuro-oncologyGap43-dependent MitochondriaMitochondrial FunctionGlioma +9

Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer

Hannah N. Bell, Amanda K. Huber, Rashi Singhal, +23

Cell Metabolism

Cancer ImmunosurveillanceColorectal CancerMedicineCell BiologyTumor Microenvironment +1

Uridine-derived ribose fuels glucose-restricted pancreatic cancer

Zeribe C. Nwosu, Matthew H. Ward, Peter Sajjakulnukit, +26

Nature

Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways

Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, +81

Cancer Discovery