Targeted oncogene activation by site-specific recombination in transgenic mice.

Merja Lakso, Brian Sauer, B Mosinger, +5

Proceedings of the National Academy of Sciences

Developmental BiologyTransgenic Mouse ModelsReverse GeneticsSite-directed RecombinationVivo Transgene Modulation +9

A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.

Domenico Accili, C. Simone Fishburn, John Drago, +10

Proceedings of the National Academy of Sciences

Knockout MouseBehavioral NeuroscienceFunctional SelectivityGeneticsPsychiatric Genetics +13

Animal model of Gaucher's disease from targeted disruption of the mouse glucocerebrosidase gene

Victor L. J. Tybulewicz, Michel L. Tremblay, LaMarca, +10

Nature

GeneticsPathogenesisAnimal ModelGenetic EngineeringPathology +3

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

Paul A. Overbeek, A.B. Chepelinsky, Jaspal S. Khillan, +2

Proceedings of the National Academy of Sciences

Ocular DiseaseMolecular RegulationGeneticsA-crystallin GeneMolecular Biology +17

Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

S Radovick, Susan Wray, E Lee, +6

Proceedings of the National Academy of Sciences

ImmunologyReproductive BiologyReproductive EndocrinologyNeuroendocrine MechanismPublic Health +14

Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease.

Shoji Yamanaka, Mark D. Johnson, Alexander Grinberg, +5

Proceedings of the National Academy of Sciences

Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice.

Pasi A. Jänne, Sharon F. Suchy, David J. Bernard, +6

Journal of Clinical Investigation

GeneticsMolecular GeneticsDisease Gene IdentificationFunctional OverlapMurine Inpp5b +15

A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice.

C.W. Pittius, Lothar Hennighausen, E Lee, +4

Proceedings of the National Academy of Sciences

GeneticsReproductive BiologyTransgenic MiceMammary Gland DevelopmentTranscriptional Regulation +14

D1 dopamine receptor-deficient mouse: cocaine-induced regulation of immediate-early gene and substance P expression in the striatum

John Drago, Charles R. Gerfen, H Westphal, +1

Neuroscience

Immediate-early GeneCocaine-induced RegulationMolecular NeurosciencePsychoactive DrugAddiction +9

Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA.

Geoffrey R. Kitchingman, S P Lai, H Westphal

Proceedings of the National Academy of Sciences

Viral ReplicationDnaViral Polymerase StructureGeneticsMolecular Biology +16